Patients who feel fatigue often say that even a small effort, such as walking across a room, can seem like too much.Īnemia, which is a low level of red blood cells It is a common problem for people with amyloidosis. Other general symptoms of amyloidosis include:įatigue, which is extreme exhaustion or tiredness. This condition is known as peripheral neuropathy. Numbness, tingling, or weakness in the arms or legs may develop. Patients may experience painful paresthesias (unusual sensations), numbness and balance difficulties, vomiting, diarrhea, constipation, sweating, or sexual problems. Disorders of peripheral nerves are the most common neurological complication of amyloidosis. Amyloidosis of the lungs may cause problems with breathing, including shortness of breath. Amyloidosis of the thyroid gland may cause a goiter, which is a noncancerous swelling of the thyroid gland. It may also cause problems with the esophagus, including gastroesophageal reflux disease (GERD). Amyloidosis of the gastrointestinal tract may cause problems with the digestion and absorption of food nutrients, diarrhea or constipation, bleeding, blockages, and a thickened tongue, called macroglossia. Amyloidosis of the heart may cause an irregular heartbeat, called an arrhythmia enlarge the heart and cause poor heart function, resulting in fluid buildup, an irregular heartbeat, shortness of breath, or chest pain. This may cause pain in the upper abdomen, swelling in the abdomen, and changes in liver enzymes that can be found using blood tests. Amyloidosis may cause the liver to grow larger and affect its ability to function normally. Decreased urine output and changes in creatinine clearance tests, a blood test to measure kidney function, may be present. As a result, large amounts of protein may be found in the urine, causing “foamy” urine. Amyloidosis in the kidneys will reduce the kidneys’ ability to filter waste and break down proteins. Symptoms of amyloidosis are usually determined by the organ or function that is affected by the protein buildup. All of these factors can make diagnosing amyloidosis challenging because the symptoms may be similar to those of numerous other diseases and conditions that are more common than amyloidosis. Or, the cause of a symptom may be another medical condition.

Sometimes, people with amyloidosis do not have any of the signs and symptoms detailed below. Together, signs and symptoms can help describe a medical problem. A sign is something that other people can identify and measure, such as a fever, rash, or an elevated pulse. A symptom is something that only the person experiencing it can identify and describe, such as fatigue, nausea, or pain. People with amyloidosis may experience the following symptoms or signs. The symptoms of amyloidosis can vary widely, depending on the specific organ or number of organs affected by the buildup of amyloid protein. ON THIS PAGE: You will find out more about body changes and other things that can signal a problem that may need medical care.

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